The most widely known substances that have been investigated for
treating cognitive deterioration in the aged are cerebral vasodilators,
Gerovital H3, psychostimulants, "nootropics," neuropeptides, and
neurotransmitters. The rationale for the choice of specific agents has
shifted as our conceptions regarding the origins of cognitive decline have
changed; we now know that most cognitive deterioration occurs independently
of arteriosclerotic vascular changes. Substances currently being
investigated because of their effects on brain electrophysiology, on
neurohumoral processes, or on central neurotransmitters show promise.
Abstract Teaser