The authors successfully treated four patients who had irreversible CNS
lesions and socially disabling aggressiveness and outbursts of rage, which
had not been affected by high doses of major tranquilizers or
anticonvulsants, with 320-520 mg/day of propranolol. Disorientation, memory
impairment, and psychotic thought processes associated with the CNS lesions
were not altered by the propranolol.