The authors report on six refractory manic or schizo-affective manic
male outpatients who failed to respond to lithium combined with a
neuroleptic. A beneficial response was noted in most patients when
reserpine was substituted for their currently prescribed standard
neuroleptic; in some cases lithium dosage could then be reduced. No major
side effects were encountered. The use of reserpine may offer an
alternative mode of therapy for manic patients who cannot tolerate large
doses of lithium or do not completely respond to lithium either alone or in
combination with a standard neuroleptic.
Abstract Teaser