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The American Journal of Psychiatry, VOL. 136, No. 6

REGULAR ARTICLES | June 01, 1979

Variable attenuation of amphetamine effects by lithium

Am J Psychiatry 1979;136:806-810.

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Abstract

In an open study of 8 subjects, approximately half showed some attenuation of CNS stimulant effects of amphetamine after pretreatment with lithium. Two showed specific blockade of euphoria, with persistence of some CNS stimulant effects. In 3 subjects lithium did not appear to affect the response to amphetamine. Lithium caused significant attenuation of the amphetamine-induced increase in systolic blood pressure for the group as a whole.

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