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Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para- tyrosine and l-dopa

Published Online:https://doi.org/10.1176/ajp.136.3.311

Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.

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