The authors note an apparent unawareness of, as well as a paucity of
recent literature pertaining to, hyperpyrexia as a complication of
psychotropic drug treatment. They report a case of hyperpyrexia in a
patient receiving psychotropic agents during a summer heat wave; massive
muscle destruction (rhabdomyolysis) with myoglobinuria and acute renal
failure make this case of particular interest. Causative mechanisms,
preventive measures, and the benefits of prompt recognition and treatment
of this condition are discussed.