5-IT is a little-known 5-positional isomer of α-methyltryptamine, a synthetic indole analog of amphetamine. This molecule shows a bicyclic structure consisting of a six-membered benzene ring fused with a five-membered nitrogen-containing pyrrole ring, and it is considered the only psychoactive α-methyltryptamine positional isomer (3). To our knowledge, no formal study has investigated the pharmacological and toxicological properties of this substance. Users have reported that the desired effects include mild euphoria, mood enhancement, greater sociability and energy, and intensification of sensory experience. Users have also reported untoward effects such as anxiety, psychomotor agitation, confusion, insomnia, sweating, restlessness, tremors, jaw clenching, dilated pupils, and increases in heart rate, blood pressure, and body temperature. 5-IT is generally consumed intranasally or orally, and the dosage range reported by users is between 50 mg and 120 mg. The onset of action occurs within 30 minutes to 1 hour of ingestion, and the effects may last up to 10 hours (1, 4).