Prompted by an interest in the similarity of brain and
tuberoinfundibular systems, the authors studied butaclamol-specific
neuroleptic and apomorphine binding in pituitary and striatum after chronic
haloperidol and acute apomorphine treatment. Striatal binding increases but
pituitary binding decreases in haloperidol-treated rats. Pituitary binding
changes rapidly in response to apomorphine exposure and striatal binding
does not. These findings suggest that factors influencing binding differ in
these two tissues.