Relapse rates of the first 35 unipolar and bipolar II manic-depressive
patients who entered the controlled phase of a continuing evaluation of the
prophylactic value of lithium alone or in combination with imipramine were
analyzed. Lithium had a prophylactic effect in unipolar patients and
possibly in bipolar II patients. Imipramine did not have a prophylactic
effect in either group of patients.