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The American Journal of Psychiatry, VOL. 135, No. 5

REGULAR ARTICLES | May 01, 1978

Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report

Am J Psychiatry 1978;135:570-572.

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Abstract

Relapse rates of the first 35 unipolar and bipolar II manic-depressive patients who entered the controlled phase of a continuing evaluation of the prophylactic value of lithium alone or in combination with imipramine were analyzed. Lithium had a prophylactic effect in unipolar patients and possibly in bipolar II patients. Imipramine did not have a prophylactic effect in either group of patients.

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