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The effect of high doses of vitamin B6 on autistic children: a double- blind crossover study
Am J Psychiatry 1978;135:472-475.
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Abstract

The authors used data from an earlier nonblind study to identify 16 autistic-type child outpatients who had apparently improved when given vitamin B6 (pyridoxine). In a double-blind study each child's B6 supplement was replaced during two separate experimental trial periods with either a B6 supplement or a matched placebo. Behavior was rated as deteriorating significantly during the B6 withdrawal.

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