The therapeutic effects of benzodiazepines in psychoneurosis may depend
in part on their ability to release or disinhibit a patient's anxiety-
suppressed gratification-seeking behavior. Benzodiazepines may disinhibit
behavior by reducing the activity of serotonin (and possibly acetylcholine)
neurons in the brain's "punishment" system. Reduction of serotonin
transmission may be due to a facilitation of gamma- aminobutyric acid
(GABA)-mediated presynaptic inhibition at the serotonin nerve terminal.