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The American Journal of Psychiatry, VOL. 134, No. 6

REGULAR ARTICLES | June 01, 1977

Brain mechanisms associated with therapeutic actions of benzodiazepines: focus on neurotransmitters

Am J Psychiatry 1977;134:662-665.

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Abstract

The sedative, muscle relaxant, antianxiety, and anticonvulsant effects of benzodiazepines may involve several distinct mechanisms because dissociation among these actions can be demonstrated with various drugs. Neurotransmitters displaying prominent interactions with benzodiazepines include gamma-aminobutyric acid (GABA), glycine, norepinephrine, and serotonin.

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