The authors present five case reports illustrating that 10-20 mg of
protriptyline in a single dose at bedtime can effectively control arousal
dysfunction (sleep drunkenness and hypersomnia) and the narcolepsycataplexy
syndrome without the apparent development of tolerance and without the side
effects that are frequent complications of treatment with other agents.
Although protriptyline was efficacious in controlling symptoms, it was
found to have relatively poor REM sleep- suppressing properties.