In the first part of this overview the author reviewed the clinical
literature on prophylactic treatment of schizophrenia with maintenance
antipsychotic drugs. In this second part he reviews the literature on
maintenance treatment of affective disorders with lithium and tricyclics.
He concludes that the growing realization that maintenance treatment is
necessary to prevent recurrences of both mania and depression in bipolar
disease and depression in unipolar disease is one of the most important
advances in psychiatric therapeutics. The effectiveness of maintenance
treatment provides the potential for a truly preventive approach to the
treatment of affective disorders.