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The American Journal of Psychiatry, VOL. 131, No. 6

Articles | June 01, 1974

Studies of EN-1639A (Naltrexone): A New Narcotic Antagonist

RICHARD B. RESNICK; JAN VOLAVKA; ALFRED M. FREEDMAN; MURIEL THOMAS

Am J Psychiatry 1974;131:646-650.

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Assistant Professor, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

Associate Professor, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

Professor and Chairman, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

Instructor, Department of Psychiatry, New York Medical College, 5 East 102nd St., New York, N.Y. 10029

1974, The American Psychiatric Association

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Abstract

The narcotic antagonist EN-1639A (naltrexone) was studied in 37 heroin addicts and found to be clinically useful, with a low incidence of side effects, lack of toxicity, high degree of acceptability to the patient, and capacity to antagonize the euphoric effects of heroin for up to 72 hours after a single oral dose. These findings provide a basis for expanding studies of the clinical efficacy of naltrexone in the treatment of opiate dependence.

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