The Use of Lithium in Affective Disorders, III: A Double-Blind Study of Prophylaxis in Bipolar Illness
Abstract
The authors studied 52 manic-depressive patients who were assigned to either lithium or placebo during their normal interval phases for periods up to 28 months. Patients receiving lithium had fewer manic and depressive episodes per patient-year than placebo patients. However, this difference may have been due to a sample bias produced by a large dropout rate among patients who had manic episodes. The findings also suggest a relationship between response to lithium and family history of bipolar illness.
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