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The American Journal of Psychiatry, VOL. 130, No. 9

Articles | September 01, 1973

The Use of Lithium in Affective Disorders, III: A Double-Blind Study of Prophylaxis in Bipolar Illness

FRANK STALLONE; EDWARD SHELLEY; JULIEN MENDLEWICZ; RONALD R. FIEVE

Am J Psychiatry 1973;130:1006-1010.

Associate Research Scientist, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032

Ward Administrator, Metabolic Research Unit, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032

Visiting Research Fellow, Belgian American Education Foundation, Department of Medical Genetics, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Senior Psychiatrist, Brugmann Psychiatric Hospital, Brussels, Belgium; and Professor of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York, N.Y.

Chief of Psychiatric Research, Department of Internal Medicine and Metabolic Research Unit, New York State Psychiatric Institute, 722 West 168th St., New York, N.Y. 10032 and Professor of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York, N.Y.

1973, the American Psychiatric Association

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Abstract

The authors studied 52 manic-depressive patients who were assigned to either lithium or placebo during their normal interval phases for periods up to 28 months. Patients receiving lithium had fewer manic and depressive episodes per patient-year than placebo patients. However, this difference may have been due to a sample bias produced by a large dropout rate among patients who had manic episodes. The findings also suggest a relationship between response to lithium and family history of bipolar illness.

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