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The American Journal of Psychiatry, VOL. 130, No. 8

Articles | August 01, 1973

Urinary Cyclic AMP in Periodic Catatonia

THOMAS L. PERRY; GEORGE I. DRUMMOND; SUSAN HEMMINGS; SHIRLEY HANSEN; LEIV R. GJESSING

Am J Psychiatry 1973;130:927-929.

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Professor, Department of Pharmacology, University of British Columbia, Vancouver 8, B.C., Canada

Research Assistant, Department of Pharmacology, University of British Columbia, Vancouver 8, B.C., Canada

Research Associate with the Department of Pharmacology, University of British Columbia, Vancouver 8, B.C., Canada

Chief of the Central Laboratory, Dikemark Sykehus, Asker, Norway

1973, The American Psychiatric Association

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Abstract

Urinary excretion of 3',5'-cyclic adenosine monophosphate (cyclic AMP) was measured in two patients with long-established periodic catatonia. One patient exhibited profound stupor in his psychotic phases, while the other exhibited catatonic excitement. No significant differences in urinary cyclic AMP levels were found in either patient between the interval and psychotic phases, nor were there any significant changes in cyclic AMP excretion at or just before the time of abrupt switch from the interval of normality to catatonic stupor or excitement.

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