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Antagonism of Guanethidine by Chlorpromazine
DAVID S. JANOWSKY; M. KHALED EL-YOUSEF; JOHN M. DAVIS; WILLIAM E. FANN
Am J Psychiatry 1973;130:808-812.
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Associate Professor of Psychiatry and Assistant Professor of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. 37203

Assistant Professor of Psychiatry and Instructor of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. 37203

Professor of Psychiatry and Assistant Professor of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. 37203

Associate Professor of Psychiatry, Duke University School of Medicine, Durham, N.C.

1973, The American Psychiatric Association

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Abstract

Chlorpromazine was found to reverse the antihypertensive effects of guanethidine six times in use with four moderately or severely hypertensive psychiatric patients. Haloperidol and thiothixene caused similar effects. It is postulated that this drug-drug interaction occurs because chlorpromazine blocks the neuronal amine-guanethidine uptake pump, thereby denying guanethidine access to its site of action.

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