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The American Journal of Psychiatry, VOL. 129, No. 1

Articles | July 01, 1972

Lithium Response in Unipolar Versus Bipolar Depression

FREDERICK K. GOODWIN; DENNIS L. MURPHY; DAVID L. DUNNER; WILLIAM E. BUNNEY, JR.

Am J Psychiatry 1972;129:44-47.

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New York State Psychiatric Institute, New York, N.Y.

Director, Division of Narcotic Addiction and Drug Abuse, NIMH

1972, American Psychiatric Association

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Abstract

The antidepressant effects of lithium carbonate were evaluated in a group of 52 hospitalized depressed patients, using a longitudinal double-blind design that involved alternating drug and placebo periods in the same patient. Thirty-six of the 52 patients showed some improvement on lithium, including 15 who had complete remission of symptoms. Virtually all of the antidepressant responses occurred in patients with a past history of mania or hypomania (the bipolar group).

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