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Childhood Schizophrenia and 47, XXY Klinefelter's Syndrome
MICHAEL A. SPERBER; LUCY SALOMON; MARY H. COLLINS; MORRIS STAMBLER
Am J Psychiatry 1972;128:1400-1408.
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Clinical Instructor in Psychiatry, Harvard Medical School, Assistant Attending Psychiatrist, McLean Hospital, Belmont, Mass. 02178, and Lecturer on Social Relations, Harvard University

Clinical Fellow in Psychiatry, Beth Israel Hospital and Harvard Medical School, Boston, Mass.

Clinical Fellow in Psychiatry, Harvard Medical School, Resident Psychiatrist, McLean Hospital, Belmont, Mass. 02178

Clinical Fellow in Child Psychiatry, Beth Israel Hospital and Harvard Medical School, Boston, Mass.

1972, American Psychiatric Association

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Abstract

Klinefelter's syndrome is a genetically transmitted endocrinological disorder characterized by a complement of 44 autosomes with an XXY sex-chromosome complex; it is frequently accompanied by neuropsychiatric disorders, although childhood schizophrenia has not been previously reported. Noting a statistically significant increase in the incidence of Klinefelter's syndrome in a schizophrenic population, the authors advance several verifiable hypotheses: adult Klinefelter schizophrenics may have psychotic processes of early origin, a high percentage of children currently diagnosed as psychotic may have Klinefelter's syndrome, and those with Klinefelter's syndrome may have increased susceptibility to develop schizophrenia.

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