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Articles   |    
Schizophrenia in Veteran Twins: A Diagnostic Review
MARTIN G. ALLEN; STEPHEN COHEN; WILLIAM POLLIN
Am J Psychiatry 1972;128:939-945.
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Assistant Professor of Psychiatry, Georgetown University Medical School, 3800 Reservoir Rd., N.W., Washington, D.C. 20007

Clinical Associate, Section on Twin and Sibling Studies, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.

Chief, Section on Twin and Sibling Studies, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.

1972, American Psychiatric Association

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Abstract

The authors performed a systematic diagnostic review of the records of all twin pairs with a psychotic diagnosis in the Veteran Twin Registry. They found 274 pairs of twins (313 individuals) in which one or both were "clearly" schizophrenic, a frequency of 0.98 percent. The monozygotic (MZ) concordance was 27.4 percent, the dizygotic (DZ) concordance was 4.8 percent, and the MZ/DZ ratio was 5.7. Compared with the results of a computer search, these results present a higher MZ concordance and MZ/DZ ratio. The authors also review the results of the major twin studies of schizophrenia, which indicate that both genetic and environmental factors are significant in the occurrence of schizophrenia.

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