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The American Journal of Psychiatry, VOL. 128, No. 7

Articles | January 01, 1972

Perceptual Challenge to Measure Illness and Therapy

AMEDEO S. MARRAZZI; SHARON WOODRUFF; DENIS KENNEDY

Am J Psychiatry 1972;128:886-890.

Professor of Psychiatry and Neuropharmacology and Chief of Neuropharmacology, University of Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139

Acting Chief of Neurology, University of Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139

Research Resident, University of Missouri Institute of Psychiatry, 5400 Arsenal St., St. Louis, Mo. 63139

1972, American Psychiatric Association

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Abstract

The dissociation produced in the auditory modality by a challenge with LSD can be quantitated by an instrumental perception test. Chlorpromazine can protect against this dissociation, and its efficacy can be measured by changes in auditory perception. The author describes this quantitative instrumental procedure. which is being developed into a "clinical yardstick" to measure dissociative mental dysfunction and illness, its intensity, and its response to therapy.

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