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The American Journal of Psychiatry, VOL. 127, No. 8

Articles | February 01, 1971

Effectiveness of Antidepressant Drugs: A Triple-Blind Study Comparing Imipramine, Desipramine, and Placebo

ABRAHAM HELLER; RORRY ZAHOUREK; H. G. WHITTINGTON

Am J Psychiatry 1971;127:1092-1095.

Director, Community Mental Health Center, Department of Health and Hospitals, W. Sixth Ave. and Cherokee St., Denver, Cob. 80204

Psychiatric Research Nurse, Community Mental Health Center, Department of Health and Hospitals, W. Sixth Ave. and Cherokee St., Denver, Cob. 80204

Director of Psychiatric Services, Community Mental Health Center, Department of Health and Hospitals, W. Sixth Ave. and Cherokee St., Denver, Cob. 80204

1971, American Psychiatric Association

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Abstract

The authors made a triple-blind comparison of placebo, imipramine, and desipramine in severely depressed hospitalized psychiatric patients. They found that both drugs were superior to placebo, that imipramine was the drug of choice in treating these patients, and that imipramine was superior to desipramine and placebo in the rapidity of action and in the degree of improvement noted.

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