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The American Journal of Psychiatry, VOL. 127, No. 8

Articles | February 01, 1971

The Reversal of Anticholinergic Drug-Induced Delirium and Coma with Physostigmine

JON F. HEISER; JOHN C. GILLIN

Am J Psychiatry 1971;127:1050-1054.

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Staff Psychiatrist, U. S. Naval Hospital, Oakland, Calif. 94627

Clinical Associate, National Institute of Mental Health, Bethesda, Md. 20014

1971, American Psychiatric Association

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Abstract

Although its use for this purpose is not well recognized, physostigmine provides an effective and safe treatment for delirium and coma caused by anticholinergic agents such as atropine, scopolamine, and hyoscyamine. The authors summarize the supporting evidence and outline a recommended procedure.

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