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The American Journal of Psychiatry, VOL. 127, No. 5

Articles | November 01, 1970

Carbon Disulfide Intoxication from Overdosage of Disulfiram

FRANCIS J. KANE, JR.

Am J Psychiatry 1970;127:690-694.

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Associate professor of psychiatry, department of psychiatry, North Carolina Memorial Hospital, Chapel Hill, N.C. 27514

1971, American Psychiatric Association

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Abstract

The author discusses a case of acute brain syndrome with depression, peripheral neuropathy, and transient parkinsonism following ingestion of large amounts of disulfiram. He reviews clinical and experimental evidence bearing on the relationship between disulfiram and its metabolite, carbon disulfide, and reviews similarities in the syndromes associated with the toxicity of each.

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