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The American Journal of Psychiatry, VOL. 126, No. 9

Articles | March 01, 1970

A Double-Blind Comparison of Lithium and Chlorpromazine in the Treatment of Manic States

GOTTFRIED SPRING; DANIEL SCHWEID; CARL GRAY; JOEL STEINBERG; MARC HORWITZ

Am J Psychiatry 1970;126:1306-1310.

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Teaching fellow, department of psychiatry, University Hospitals of Cleveland, Ohio 44106

Residents, department of psychiatry, University Hospitals of Cleveland, Ohio 44106

Psychiatric Institute, Washington, D. C.

United States Air Force

1970, American Psychiatric Association

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Abstract

Lithium, at a dosage of 1,800 mg. daily, was found to be effective in the treatment of acute manic states. However, when compared with chlorpromazine by means of a double-blind technique using stringent diagnostic criteria, no significant difference between the two drugs was noted. In regard to the prophylactic effect of lithium, the data presented indicate that this question is still unresolved.

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