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Articles   |    
Family History Studies: V. The Genetics of Mania
THEODORE REICH; PAULA J. CLAYTON; GEORGE WINOKUR
Am J Psychiatry 1969;125:1358-1369.
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Resident, department of psychiatry, Washington University School of Medicine, St. Louis, Mo. 63110

Assistant professor, department of psychiatry, Washington University School of Medicine, St. Louis, Mo. 63110

Professor, department of psychiatry, Washington University School of Medicine, St. Louis, Mo. 63110

1968-69, American Psychiatric Association

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Abstract

In this study of the families of 59 manic-depressive, manic type probands, the predominant affective illness among the family members was depression without mania, although mania was frequent. The findings suggest that genetic transmission occurred by a sex-linked single or double dominant gene. In two families affective disorder was linked to color blindness, implying that the X-linked gene for manic-depressive psychosis is on the short arm of the X chromosome.

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