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Diagnosis and Treatment of Drug Dependence of the Barbiturate Type
ABRAHAM WIKLER
Am J Psychiatry 1968;125:758-765.
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Professor of psychiatry and pharmacology, department of psychiatry, University of Kentucky College of Medicine and University Hospital, Lexington, Ky. 40506

1968-69, American Psychiatric Association

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Abstract

The basic principles in treatment of patients suspected of, or known to be, physically dependent on barbiturates, nonbarbiturate sedatives, and/or "minor tranquilizers" are: stabilization on pentobarbital in daily amounts and frequency of dosage sufficient to completely suppress barbiturate-type abstinence phenomena and produce minimal signs of barbiturate intoxication; and progressive reduction of pentobarbital dosage at the rate of not more than 100 mg. a day after three to five days of stabilization.

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