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The American Journal of Psychiatry, VOL. 125, No. 4

Articles | October 01, 1968

Lithium Carbonate: A Clinical Study

HARRY ZALL; PER-OLOF G. THERMAN; J. MARTIN MYERS

Am J Psychiatry 1968;125:549-555.

Senior resident in psychiatry, Institute of the Pennsylvania Hospital, 111 N. 49th St., Philadelphia, Pa. 19139

Director of the clinical laboratory and director of the resident research training program, Institute of the Pennsylvania Hospital, 111 N. 49th St., Philadelphia, Pa. 19139

Medical director, Institute of the Pennsylvania Hospital, 111 N. 49th St., Philadelphia, Pa. 19139

1968-69, American Psychiatric Association

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Abstract

Lithium carbonate has been widely acclaimed as a useful drug in the treatment of manic-depressive psychoses. The results of this clinical study emphasize that lithium is highly beneficial in preventing and alleviating acute mania and the hypomanic aspects of schizo-affective psychoses. When used alone, lithium was found to be relatively ineffective as an antidepressant. However, in combination with a tricyclic or MAO-inhibiting antidepressant, it was often effective in alleviating depressions, including those refractory to single psychopharmacological agents.

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