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Published Online:https://doi.org/10.1176/ajp.125.4.530

Two sets of experiments were conducted to study the effects of lithium on the gross electrical activity of the cat brain. The first series, designed to study acute effects by means of recording evoked potentials using encephale isolé cats, suggests that the orbito-frontal cortex is a primary brain locus for the immediate effects of lithium. The second series of experiments, designed to study chronic effects, suggests that lithium produces widespread EEG slowing after it has been administered for seven days; marked behavioral changes were also observed in these cats following the seven-day course of lithium administration.

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