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Long-Term Chlorpromazine Retention and Its Modification by Steroids

Published Online:https://doi.org/10.1176/ajp.125.2.243

Urine chlorpromazine excretion was measured in 28 senile patients who had been unmedicated for 12 to 18 months. Significant amounts of chlorpromazine were often detectable. The excretion rate of chlorpromazine could be increased by administration of cortisone and decreased by administration of androgen.

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