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The American Journal of Psychiatry, VOL. 125, No. 1

Articles | July 01, 1968

Serum Macroglobulin (S19) in Families of Monozygotic Twins Discordant for Schizophrenia

JAMES R. STABENAU; WILLIAM POLLIN; LOREN MOSHER

Am J Psychiatry 1968;125:109-112.

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Section on twin and sibling studies, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Md. 20014

Assistant professor of psychiatry, Yale University Medical School, New Haven, Conn.

1968-69, American Psychiatric Association

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Abstract

The authors studied 16 pairs of monozygotic twins—12 pairs of twins discordant for schizophrenia and four pairs of nonschizophrenic control twins—and their parents to determine the relationship between serum macroglobulin level and schizophrenia. They found no significant relation between the two factors. Evidence from these and other data suggests that serum macroglobulin levels are more influenced by factors based on sex and genetic makeup than by environment.

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