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Adrenal Cortical Activity in Pathological Emotional States : A Review
ROBERT T. RUBIN; ARNOLD J. MANDELL
Am J Psychiatry 1966;123:387-400.
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Biochemical Correlates Laboratory, Neuropsychiatric Institute, UCLA Center for the Health Sciences, Los Angeles, Calif. 90024

1966-67, American Psychiatric Association

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Abstract

Changes in adrenal cortical activity have been correlated with certain pathological emotional states. Heightened activity occurs concomitantly with depressive reactions of various types and in certain phases of acute schizophrenic reactions. The psychological variable that correlates most closely with increased adrenal cortical secretion is loss of "ego defense strength," that is, absence of denial with awareness of illness. Behavioral observations and biochemical methodologies in the studies reviewed are discussed, and several alternative mechanisms of adrenal cortical activation are postulated.

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