BIOCHEMICAL STUDIES OF FAMILIES OF SCHIZOPHRENIC PATIENTS
Abstract
Thirty-five schizophrenic patients were separated into two groups on the basis of L/P ratio studies. Twenty-one patients manifested an increased plasma protein factor as reflected by a mean L/P ratio above 11.5—the high-factor group. Fourteen patients showed no increase in protein factor as evidenced by a mean L/P ratio below 11.5—the low-factor group.
L/P ratio determinations were made on 117 parents and siblings of both the high- and low-factor groups of patients. There is a significantly greater proportion of high L/P ratios in families of the high-factor patients than in families of low-factor patients.
The data, while demonstrating a familial trend, are not sufficiently definitive to allow a specific genetic interpretation. Previous studies have indicated that environmental factors might also play a significant role.
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