EFFECTS OF CHLORPROMAZINE ON BRAIN TISSUE RESPIRATION
Abstract
This work demonstrates that there is a biphasic effect on brain tissue respiration with respect to time interval after chlorpromazine administration to an intact animal. The first phase, lasting about 16 hours in the rat, reflects an inhibition of respiratory activity while the second, persisting about 4 days, reflects an enhancement of respiration. It is not clear at this point whether this biphasic effect is due to a peculiarity of metabolic activity or simply represents a different rate of penetration into cortical and subcortical structures.
We have demonstrated that chlorpromazine can induce opposite effects on brain tissue respiration in different parts of the brain. The hemispheres including the cerebellum show an increased respiration while the midbrain and stem show a depression of respiration following chlorpromazine administration.
Access content
To read the fulltext, please use one of the options below to sign in or purchase access.- Personal login
- Institutional Login
- Sign in via OpenAthens
- Register for access
-
Please login/register if you wish to pair your device and check access availability.
Not a subscriber?
PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.
Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).