Imipramine-promazine therapy resulted in an overall good clinical response in 80% of a group of patients with depressive syndromes. Response of symptoms of anxiety alone was over 90%. Patients were treated privately, and received intensive psychotherapy which included other members of the family. Most patients were very comfortable on the mixture. Serious side effects were few and blood pressure changes were minimal. Additional dosage of phenothiazine was necessary in some cases, especially at night, to induce sleep. The Imipramine-promazine combination appears to be highly effective, and would seem to be particularly useful in this new capsule form for the general practitioner and in outpatient clinics.