Mephenoxalone appears to be a useful medication for cases demonstrating 14 and 6 per second spikings. Its activity warrants further investigation in the areas of brain damage, especially in the so-called diffuse brain damaged child. Mephenoxalone was used in 31 children with various diagnoses. It proved helpful in 2 types of therapy: drug-symptom focused and psychotherapy-drug adjunctive. Improvement of excellent and good ratings was achieved in 55% of the former and 75% of the latter groups.