Pathological and clinical findings were reviewed in 50 schizophrenic patients. Only 2, both alcoholics, had no notable pathological brain abnormalities. Vascular diseases and malformations of the brain were particularly frequent. The diversity of findings was a prominent feature, and tended to support the thesis that schizophrenia is a syndromic diagnosis. The series suggests that some of the findings may be causally related to the schizophrenic symptoms.