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CLINICAL NOTES   |    
EFFICACY OF TRIFLUOPERAZINE IN CHRONIC MENTAL ILLNESS
ROBERT B. CAHAN
Am J Psychiatry 1960;116:838-839.
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Norristown State Hospital, Norristown, Pa.

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Abstract

Trifluoperazine is considered to be of limited usefulness and considerable toxicity in an elderly female population.The 8 patients with increased muscular rigidity having 4 of their number improved by Stelazine should be contrasted with the absence of psychiatric improvement among the 8 women with muscular weakness. Investigation of this phenomenon may reveal clues to the operation of trifluoperazine.On the positive side, no agranulocytic, hepatotoxic, or biliary static effects were noted. A therapeutic agent which can improve the ward management of one-fifth of the severely and chronically ill patients should be considered as part of the psychotherapeutic armamentarium.

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