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Am J Psychiatry 1959;116:337-338.
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1. The syndrome of akathisia has been defined and described. It appears to be a manifestation of the Parkinson syndrome.2. Two cases of akathisia are reported. They both occurred during administration of phenothiazine tranquilizing drugs, and were relieved by changing or stopping the drug and by adding an anti-Parkinson drug. No attempt was made to determine the necessity for adding the anti-Parkinson drug when the tranquilizer was changed, though Kruse(4) reports that "these reactions . . . were always controllable" by anti-Parkinson drugs alone.3. Akathisia is a syndrome which occurs during the administration of high doses of tranquilizing drugs. Whenever a patient fails to respond to the administration of high doses of these medicines or when he seems to have a paradoxical effect from them, the possibility of akathisia should be considered and appropriate treatment instituted.4. Appropriate treatment of the condition appears to be, at this time, a reduction or change in the tranquilizing drugs used, plus the addition of an anti-Parkinson drug such as Cogentin, Pagitane, or Kemadrin.

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