0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
CLINICAL FINDINGS IN THE USE OF TOFRANIL IN DEPRESSIVE AND OTHER PSYCHIATRIC STATES
BENJAMIN POLLACK
Am J Psychiatry 1959;116:312-317.
text A A A
PDF of the full text article.
Abstract

1. Preliminary observation would indicate that Tofrānil is a useful drug in the treatment of depressive states. It is not a tranquilizer and, therefore, is of little value in other conditions. It is a promising drug which can be used as an anti-depressant. However, its indication and scope must be studied for a longer period to determine what symptoms respond best to it.2. The effect of Tofrānil in many patients can be increased by the concomitant use of a tranquilizer or a stimulant. In a number of patients Tofrānil, by removing the depressive elements, frees and exaggerates anxiety.3. It can be used in combination with electric shock or after electric shock as a maintenance dose.4. It is of little value in the treatment of schizophrenics and in paranoid types may often aggravate the condition and break down an unstable equilibrium to which the patient has become adjusted.5. The combined use of Tofrānil and a tranquilizer is helpful in certain psychoneurotic states, associated with anxiety or with reactive depressions.6. It is of value in the treatment of depressions occurring in the older age group.7. High doses are unnecessary and the effective range is somewhere between 75 and 150 mgm. per day.8. For the most part, side effects are minimal, particularly in the younger age group. As one approaches the older age group, the frequency of such side effects increases, but usually they are more uncomfortable than serious. In patients over 60 there may be a tendency to sudden falls which occur without warning. It is recommended that in older patients the dosage be limited to 75 mgm. or less.9. Side effects can usually be reduced in frequency or intensity by a reduction in the dosage.10. Long-term use of the drug is apparently necessary as patients may relapse, at least in the early stages when the drug is prematurely removed. Since the drug is rapidly excreted, it is necessary to give the medication 3 times a day.

Abstract Teaser
Figures in this Article

Topics

imipramine
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Web of Science® Times Cited: 32

Related Content
Articles
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 1.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Topic Collections
Psychiatric News
PubMed Articles