1. In a double-blind study with 2 mephenesin-like drugs, B and C, and placebos used as controls, Rauwiloid and Rauwidrine therapy proved effective for the psychogenic factors of chronic alcoholism.2. Rauwiloid was most useful in relieving the symptoms of anxiety, nervousness and tension; supplementary therapy with Rauwidrine was usually effective when depression was a problem.3. Sedation with Rauwiloid and Rauwidrine is notably free of toxic effects or habituation, offering a decided advantage over the use of barbiturates, bromides or other habit-forming drugs.4. The use of Rauwiloid and Rauwidrine for the treatment of alcoholism, or other chronic states in which psychosomatic factors are prominent, merits further investigation.