After a brief enumeration of key-references to the literature on stress in psychiatry, the following specific problems are discussed on the basis of personal experiments:1. An "operational definition" of stress, based on measurable indicators of this state.2. Steroid anesthesia.3. The anticonvulsive and tranquilizing effect of steroids.4. Corticoids and muscular paralysis.5. Morphologic changes in the brain produced by corticoids.6. Stress and the inflammatory diseases.7. Stress and sexual derangements.