0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
THE EFFECT OF MESCALINE ON DIFFERENTIATED CONDITIONAL REFLEXES
WAGNER H. BRIDGER; W. HORSLEY GANTT
Am J Psychiatry 1956;113:352-360.
View Author and Article Information

Research fellow, Department of Psychiatry, Albert Einstein College of Medicine, Bronx, N. Y.

Director, Pavlovian Laboratory, Johns Hopkins Hospital, Baltimore, Md.

text A A A
PDF of the full text article.
Abstract

Mescaline produced an inhibitory state accompanied by a schizokenesis or dissociation of systems. This disharmony was also manifested in that the CS appeared to act in the same manner as the US. On this basis a neurodynamic theory of the mechanism of mescaline's actions is postulated: that under mescaline intoxication and in some mental illnesses, a dissociation of the second and first signaling systems and the unconditional reflexes occurs in which each signaling system acts as if it were the same as the more primitive system on which it is based. The secondary signals—words and ideas—come to act like the primary signals of sensations and direct impressions of reality. This theory may help explain certain psychological phenomena, e.g. dreams, hysteria, compulsions, delusions, and hallucinations. While the content of these phenomena depends on the personality of the subject and all the environmental factors that determine this personality, their mechanisms are physiological, regardless of whether one prefers a pathophysiologic or psychogenic etiology. Based on our experimental findings and the work of others, a neurodynamic pathogenesis of the psychological effects of mescaline is described.

Abstract Teaser
Figures in this Article

Topics

mescaline ; reflex
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Web of Science® Times Cited: 14

Related Content
Articles
Books
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 16.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 16.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 22.  >
Textbook of Traumatic Brain Injury, 2nd Edition > Chapter 22.  >
DSM-5™ Handbook of Differential Diagnosis > Chapter 2.  >
Topic Collections
Psychiatric News
PubMed Articles