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COMPLICATIONS OF CHLORPROMAZINE THERAPY
IRVIN M. COHEN
Am J Psychiatry 1956;113:115-121.
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Associate professor of neurology and psychiatry, University of Texas Medical Branch, Galveston.

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Abstract

1. Chlorpromazine has many undesirable effects, most of which are transient and of relatively minor clinical significance.2. Complications of greater severity occur in a significant number of cases but generally resolve rapidly and without residuals.3. Four categories of complications are distinguishable: direct or indirect action on various levels of the nervous System, allergic-type reactions, responses of indefinite origin, and indirect effects of drug action.4. Despite its numerous undesirable effects chlorpromazine is clinically a relatively safe drug.

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