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CLINICAL NOTES   |    
PRELIMINARY REPORT ON THE USE OF METHYLENE BLUE TO TERMINATE AN ANTABUSE-ALCOHOL REACTION
JACKSON A. SMITH; W. RUGLEY LIVESAY; DON W. CHAPMAN
Am J Psychiatry 1954;110:785-785.
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The Departments of Psychiatry and Medicine, Baylor University College of Medicine, Houston, Texas.

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Abstract

The reported ability of methylene blue to reactivate xanthine oxidase inhibited by antabuse in vitro has been tried clinically as a means of terminating an antabuse-alcohol reaction. Although there was some subjective relief in 2 patients following the intravenous injection of methylene blue, there was no objective evidence of its altering the antabuse-alcohol reaction in the amounts given. From these results, it seems unlikely that xanthine oxidase is of major importance in acetaldehyde metabolism in vivo; or else methylene blue in this dosage is unable to overcome the inhibition brought about by antabuse, if such an inhibition of xanthine oxidase occurs in the patient.

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