1. The literature pertaining to management of neuropsychiatric patients during transportation by air is reviewed.2. Methods employed by the military services including standard operating procedures are presented.3. Reactions to air transportation of approximately 2,100 different patients making 2,879 patient-flights are reported. Results indicate that neuropsychiatric patients can be advantageously and economically transported by air. Among the 2,879 reports studied, symptoms reported during flight were present in only 10.6%. No serious reactions occurred and no symptoms were reported that are considered to have untoward significance.4. Summarized are the results of a USAF School of Aviation Medicine research report concerning handling of neuropsychiatric patients during air transportation.