Twenty-five women with peptic ulcers were studied from the psychosomatic point of view. All exhibited profound and overt personality disorders. The majority had been rejected by the mother and turned to the father for support. Ulcer symptoms were precipitated when the supporting figure failed them. Oral aggressive feelings played an important role and were often equated with denial of femininity. This group of women with peptic ulcers had a much higher incidence of overt personality disturbances than the majority of a comparative group of men peptic ulcer patients previously studied, although frustration of dependent wishes was equally important in both groups. The shift in the sex ratio of peptic ulcer during the past 50 years suggests that cultural factors may play a role in the development of this disease.