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ON THE POSSIBILITY OF PREDICTING HUNTINGTON'S CHOREA BY ELECTROENCEPHALOGRAPHIC STUDY
BENT HARVALD
Am J Psychiatry 1951;108:295-297.
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The University Institute for Human Genetics, Copenhagen.

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Abstract

In order to study the possibility of demonstrating the presence of the morbid gene among the offspring of patients with Huntington's chorea by electroencephalography before its clinical manifestation, a total of 25 such offspring were submitted to electroencephalographic study. The examination revealed initial signs of Huntington's chorea in 2, both of whom had electroencephalograms (EEGs) of the low-voltage-fast pattern. Among the 23 clinically healthy subjects, definite EEG changes were demonstrable in only one. Another one had an EEG of the low-voltage-fast type, and 5 exhibited minor changes of doubtful significance, whereas in 16 the EEGs were normal in every respect. The writer concludes that this method does not seem to be able to afford a possibility of demonstrating the presence of the morbid gene with anything approaching certainty.

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