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The American Journal of Psychiatry, VOL. 107, No. 6

Article | December 01, 1950

A METHOD OF EVALUATING A THERAPEUTIC AGENT Results in a Study of Dibenamine

ALBERT J. STUNKARD

Am J Psychiatry 1950;107:463-467.

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The Henry Phipps Psychiatric Clinic, The Johns Hopkins Hospital.

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Abstract

1. A method of evaluating a therapeutic agent in psychiatric disorders is described. [see Tabel 1 in source pdf]2. Advantages and disadvantages of such a method are discussed.3. This method is used in a study of the effects of dibenamine in 30 patients suffering from various psychiatric disorders.4. It is demonstrated that in the dosage used dibenamine is not more effective than a placebo in the care of patients as described.5. Nausea and vomiting occurred in 11 of 30 patients receiving dibenamine, as against 2 receiving placebo.6. An increase of symptoms was found in 3 of 5 depressed patients receiving dibenamine.

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